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Virginia Tech engineers introduce thermotherapy as a chemotherapy alternative


   

Ishwar Puri Ishwar Puri

BLACKSBURG, Va., Nov. 23, 2010 – Using hyperthermia, Virginia Tech engineering researchers and a colleague from India unveiled a new method to target and destroy cancerous cells at the 63rd annual meeting of the American Physical Society held today in Long Beach, Calif.

The cancer treatment uses hyperthermia to elevate the temperature of tumor cells, while keeping the surrounding healthy tissue at a lower degree of body heat. The investigators used both in vitro and in vivo experiments to confirm their findings.

The collaborators are Monrudee Liangruksa, a Virginia Tech graduate student in engineering science and mechanics, and her thesis adviser, Ishwar Puri, professor and head of the department, along with Ranjan Ganguly of the department of power engineering at Jadavpur University, Kolkata, India.

Liangruska of Bangkok, Thailand, presented the paper at the meeting.

In an interview prior to the presentation, Puri explained to further perfect the technique they used ferrofluids to induce the hyperthermia. A ferrofluid is a liquid that becomes strongly magnetized in the presence of a magnetic field. The magnetic nanoparticles are suspended in the non-polar state. 

“These fluids can then be magnetically targeted to cancerous tissues after intravenous application,” Puri said. “The magnetic nanoparticles, each billionths of a meter in size, seep into the tissue of the tumor cell due to the high permeability of these vessels.”

Afterwards, the magnetic nanoparticles are heated by exposing the tumor to a high frequency alternating magnetic field, causing the tissue’s death by heating. This process is called magnetic fluid hyperthermia and they have nicknamed it thermotherapy.

Temperatures in the range of 41 to 45 degrees Celsius are enough to slow or halt the growth of cancerous tissue. However, without the process of magnetic fluid hyperthermia, these temperatures also destroy healthy cells.

“The ideal hyperthermia treatment sufficiently increases the temperature of the tumor cells for about 30 minutes while maintaining the healthy tissue temperature below 41 degrees Celsius,” Puri said. “Our ferrofluid-based thermotherapy can be also accomplished through thermoablation, which typically heats tissues up to 56°C to cause their death, coagulation, or carbonization by exposure to a noninvasive radio frequency, alternating current magnetic field. Local heat transfer from the nanoparticles increases the tissue temperature and ruptures the cell membranes.”

Puri added that testing showed iron oxide nanoparticles are “the most biocompatible agents for magnetic fluid hyperthermia.” Platinum and nickel also act as magnetic nanoparticles but they “are toxic and vulnerable” when exposed to oxygen.

The researchers plan to test their analytical approach by conducting experiments on various cancer cells in collaboration with Dr. Elankumaran Subbiah, assistant professor of virology in the Department of Biomedical Sciences and Pathobiology at the Virginia-Maryland Regional College of Veterinary Medicine. A senior design team consisting of five engineering science and mechanics undergraduate Virginia Tech students is fabricating an apparatus for these tests.

The College of Engineering at Virginia Tech is internationally recognized for its excellence in 14 engineering disciplines and computer science. The college's 6,000 undergraduates benefit from an innovative curriculum that provides a "hands-on, minds-on" approach to engineering education, complementing classroom instruction with two unique design-and-build facilities and a strong Cooperative Education Program. With more than 50 research centers and numerous laboratories, the college offers its 2,000 graduate students opportunities in advanced fields of study such as biomedical engineering, state-of-the-art microelectronics, and nanotechnology. Virginia Tech, the most comprehensive university in Virginia, is dedicated to quality, innovation, and results to the commonwealth, the nation, and the world.